Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

Anna Chavlovski,1 Greg A Knoll,1–3 Timothy Ramsay,4 Swapnil Hiremath,1–3 Deborah L Zimmerman1–31University of Ottawa, 2Ottawa Hospital, 3Kidney Research Centre, Ottawa Hospital Research Institute, 4Ottawa Methods Centre, Ottawa, ON, CanadaBackground: In patients with end-stage renal disease, use of vitamin D and calcium-based phosphate binders have been associated with progression of vascular calcification that might have an impact on renal transplant candidacy. Our objective was to examine management of mineral metabolism in patients wait-listed for renal transplant and to determine the impact on (...) cardiac perfusion imaging.Methods: Data was collected retrospectively on patients wait-listed for a renal transplant, being either active and on hold. Demographic data, medications, serum concentrations of calcium, phosphate, parathyroid hormone, and cardiac perfusion imaging studies were collected from the electronic health record. Chi-square and Student’s t-tests were used to compare active and on-hold patients as appropriate. Logistic regression was used to examine variables associated with worsening cardiac imaging studies.Results: The wait-listed patients were of mean age 56 ± 14 years and had been on dialysis for 1329 ± 867 days. On-hold patients had received a significantly greater total dose of calcium and were more likely to have developed worsening cardiovascular imaging studies. Total doses of calcium and calcitriol were associated with worsening cardiovascular imaging studies.Conclusion: Patients on hold on the renal transplant waiting list received higher total doses of calcium. A higher total dose of calcium and calcitriol was also associated with worsening cardiovascular imaging. Time on dialysis before transplant has been associated with worse post-transplant outcomes, and it is possible that the total calcium and calcitriol dose received contributed to these inferior outcomes.Keywords: dialysis, calcium, cardiac, transplantation. (shrink)

In this book, T. L. Short corrects widespread misconceptions of Peirce's theory of signs and demonstrates its relevance to contemporary analytic philosophy of language, mind and science. Peirce's theory of mind, naturalistic but nonreductive, bears on debates of Fodor and Millikan, among others. His theory of inquiry avoids foundationalism and subjectivism, while his account of reference anticipated views of Kripke and Putnam. Peirce's realism falls between 'internal' and 'metaphysical' realism and is more satisfactory than either. His pragmatism is not verificationism; (...) rather, it identifies meaning with potential growth of knowledge. Short distinguishes Peirce's mature theory of signs from his better-known but paradoxical early theory. He develops the mature theory systematically on the basis of Peirce's phenomenological categories and concept of final causation. The latter is distinguished from recent and similar views, such as Brandon's, and is shown to be grounded in forms of explanation adopted in modern science. (shrink)

This response to a variety of criticisms of _Charles Peirce and Modern Science_ restates and attempts to clarify and explain major themes of the book.

My purpose in what follows is not so much to defend the basic principle of utilitarianism as to indicate the form of it which seems most promising as a basic moral and political position. I shall take the principle of utility as offering a criterion for two different sorts of evaluation: first, the merits of acts of government, social policies, and social institutions, and secondly, the ultimate moral evaluation of the actions of individuals. I do not take it as implying (...) that the individual should live his life on the basis of constant evaluations of this sort. For there are different levels of decision making each with its appropriate criteria. For example, we each inevitably make many of our decisions from the point of view of our own personal self-fulfilment and this cannot regularly take a directly utilitarian form, nor should the utilitarian want it to do so. His claim is at most that we should sometimes review our life from the point of view of a kind of impersonal moral truth of a universalistic utilitarian character. (shrink)

This chapter contains sections titled: Definition of Idealism Main Idealist Thinkers Absolute Idealism Vindicated (1) Phenomenalism (2) The Physical World as Imaginative Construction (3) The Purely Structural View of the Physical World (4) Panpsychism.

But as you know... my style of ‘brilliancy’ consists in a mixture of irony and seriousness,—the same things said ironically and also seriously.Peirce’s philosophical writings are notoriously difficult. The reasons most often cited are the apparent contradictions, the long, inconclusive technical digressions, and the unfinished character of his thought. His champions instead emphasize his originality, arguing that his apparent contradictions often mark traditional dualisms subtly transcended; some discern strands of an uncompleted system. Originality, subtlety, and the need to reconstruct the (...) whole from its fragmentary expressions also pose difficulties, albeit ones rewarding. I think, however, that the problem... (shrink)

The following paragraphs were written not for print publication but for oral delivery on a celebratory occasion; their many unsupported assertions, some commonplace and some controversial, were made not to prove a thesis but to suggest a point of view—a perspective on Peirce's thought that might be taken, or not, as one wishes. The suggestion is that some difficulties are resolved and some things fall into place if we view his philosophy in its several relations to modern science. For that (...) purpose, his idea of science is of central importance and it is that idea only that I discuss here. Although drawn from the historical fact of modern science, Peirce's concept of science is unusual, radical, and difficult. In... (shrink)

This series will include monographs and collections of studies devoted to the investigation and exploration of knowledge, information, and data-processing systems of all kinds, no matter whether human, (other) animal, or machine. Its scope is intended to span the full range of interests from classical problems in the philosophy of mind and philosophical psychology through issues in cognitive psychology and sociobiology (concerning the mental capabilities of other species) to ideas related to artificial intelligence and computer science. While primary emphasis will (...) be placed upon theoretical, conceptual, and epistemological aspects of these problems and domains, empirical, experimental, and methodological studies will also appear from time to time. While most philosophers and psychologists tend to believe that the rise of cognitive psychology has occurred concomitant with the decline of operant psychology, Terry L. Smith contends that nothing could be further from the truth. He maintains that operant psychology has discovered (and continues to discover) reasonably well-confirmed causal principles of intentional behavior, which go beyond what cognitive psychology can provide, while cognitive psychology, in tum, has the potential to supply analyses (and explanations) that account for them. Smith thus advances a surprising but nonetheless illuminating perspective for appreciating the place of operant conditioning within the discipline of psychology in this rich and fascinating work. J. H. F. (shrink)

This classic study of Santayana was the first book to appear in the _Arguments of the Philosophers_ series. Growing interest in the work of this important American philosopher has prompted this new edition of the book complete with a new preface by the author reassessing his own ideas about Santayana and reflecting the new interest in the philosopher's work. A select bibliography of works published about Santayana since the book's first appearance is also included.

This paper examines a model of income and quality of life that controls the love of money, job satisfaction, gender, and marital status and treats employment status (full-time versus part-time), income level, and gender as moderators. For the whole sample, income was not significantly related to quality of life when this path was examined alone. When all variables were controlled, income was negatively related to quality of life. When (1) the love of money was negatively correlated to job satisfaction and (...) (2) job satisfaction was positively related to both income and quality of life, income was negatively related to quality of life for full-time, high-income, and male employees. When these two conditions failed to exist, income was not related to quality of life for part-time, median- or low-income, and female employees. This model provides new insights regarding the impact of the love of money and job satisfaction on the income–quality of life relationship. (shrink)

These lines conclude the account of Hermes inventing the primitive method of producing fire by friction, and it is evident that the writer had in mind σ 308: περ δ ξλα κγχανα θ;καν, αα πλαι περκηλα, νον κεκεασμνα χαλκ, cf. also ε 240. Gemoll accordingly in his edition read αα λαβν, and for so doing was rebuked by Messrs. S. and A. in their best dogmatic manner: ‘Gemoll's αα cannot be accepted; ολα is sound, though the meaning is not certain.’ (...) In other words: ‘Whether ολα makes sense or nonsense, it is right.’ Finally, they say that ολα probably means ‘whole’, and this translation is, I think, confirmed by l. 137; but then it follows that the hymn-writer was flatly contradicting the κεκεασμνα in Homer's line, and knew no more about fire-lighting than these trenchant editors. Ignition fuel has a character of its own, and from this point of view Gemoll has the advantage. (shrink)

As the editor noted in the last number Freddie Ayer, or Professor Sir Alfred Ayer, played a considerable part in launching the vast enterprise of the Bentham edition. It is fitting, therefore, that something be said in Utilitas about his achievement as a philosopher and the extent to which he falls within the same broad empiricist and utilitarian tradition to which Bentham and J. S. Mill belonged.

The relationship between Bentham's ‘enunciative principle’ and his ‘censorial principle’ is famously problematic. The problem's solution is that each person has an overwhelming interest in living in a community in which they, like others, are liable to punishment for behaviour condemned by the censorial principle either by the institutions of the state or by the tribunal of public opinion. The senses in which Bentham did and did not think everyone selfish are examined, and a less problematic form of psychological hedonism (...) than Bentham's is proposed. (shrink)

As is well known, many editors, following Valckenaer, reject the bracketed line altogether; but the omission leaves the opening clause with a very unsatisfactory ending. μπρέποντας αίθέρι, heavily stressed by its position, seems to form little less than an anticlimax, unless we assume that the stars could hardly be expected to shine in the sky. On the other hand, when line 7 is added, έμπρέποντας αίθέρ στέρας brings out clearly the fact that only certain conspicuous stars or constellations are meant—those (...) which serve as guides to the operations of agriculture and navigation, such as the Pleiades, Arcturus, and Orion, as we may see from Hesiod, Op. 609 onwards. (shrink)

This passage has caused much discussion and much variety of opinion, and it still remains doubtful whether the later commentators in their efforts at exact interpretation have been more successful than the earlier ones. The general sense is sufficiently clear. Medea is making an apology to the Chorus of sympathizing Corinthian ladies for her delay in appearing before them. So far all are agreed. The difficulties, real or unreal, arise when we begin to inquire what form the apology actually takes. (...) First of all there are doubts as to the meaning of το ς μ μᾂπο. in the Scholia. we have a gloss μῂ όρώμνο είνα. and the explanation το Xωρίςεσθα καì ᾂτν ποθεν μμάτων είνα. Many scholars have taken exception to this view on two grounds, as stated by Verrall ad loc, because ‘the sense of motion is not there, and there is no reference to any eyes in particular.’ He requires either authority or analogy for this. As far as the absence of motion is concerned, it is sufficient to refer to Thuc. 1, 7 αί δ παλααί ᾀπθαλσσης μλλον ῲκίσθησαν id I, 99ναμῄ ᾀπ οκου σ,γ. Il. B 292 μένεν ᾀπ ᾑς ᾀλòΧοο. Then there is the analogous expression αί γàρ δῂ μοᾀπ οὒατος ώδε γένοτο . As to the second objection, why is it necessary that the eyes of anyone in particular should be referred to ? There is no more ambiguity here than there is in Il Ψ 53 θâσσον ᾀπ θαλμν, where the meaning is ‘so as to be out of sight, not of me or you, but of everybody.’ In fact, it could not be maintained with any show of reason that ᾀπθαλμνand ᾀποὒατς could not mean ‘out of sight’ and ‘out of hearing’. (shrink)

Horace has told us that the author of a literary work, qui uariare cupit rem prodigialiter unam, falls into absurdities. Much more likely to meet this fate is the interpolator who has the same ambition. The above four lines are a case in point; for it is fairly certain that if this Hymn were presented to readers as it came from the hand of its author, the whole passage with its phenomenal bull and its four pacifist dogs which apparently had (...) agreed together not to bark and bite, ‘as is their nature to,’ would not be found in the text. Undoubtedly it is true, though it is by no means a marvel , that the bull which was somewhere else and the dogs which were following in his wake were not taken by the infant cattle-lifter who was satisfied, as he well might be, with a trifle of fifty cows. The veracity of the interpolater in this regard may, therefore, pass without question, and furthermore his knowledge of epic metre does not fail seriously till he reaches the fourth line, although ό δ ταρος is not really epic and λλων not λλων is required in the opening line, for he certainly did not mean, as he unwittingly says ‘other bulls,’ but ‘the others, the cows.’ After ο μνλειθεν it is quite out of the question that οĩ τε κύνες τε ταȗρος, two flagrant examples of the later article, should follow. (shrink)

Horace has told us that the author of a literary work, qui uariare cupit rem prodigialiter unam, falls into absurdities. Much more likely to meet this fate is the interpolator who has the same ambition. The above four lines are a case in point; for it is fairly certain that if this Hymn were presented to readers as it came from the hand of its author, the whole passage with its phenomenal bull and its four pacifist dogs which apparently had (...) agreed together not to bark and bite, ‘as is their nature to,’ would not be found in the text. Undoubtedly it is true, though it is by no means a marvel , that the bull which was somewhere else and the dogs which were following in his wake were not taken by the infant cattle-lifter who was satisfied, as he well might be, with a trifle of fifty cows. The veracity of the interpolater in this regard may, therefore, pass without question, and furthermore his knowledge of epic metre does not fail seriously till he reaches the fourth line, although ό δ ταρος is not really epic and λλων not λλων is required in the opening line, for he certainly did not mean, as he unwittingly says ‘other bulls,’ but ‘the others, the cows.’ After ο μνλειθεν it is quite out of the question that οĩ τε κύνες τε ταȗρος, two flagrant examples of the later article, should follow. (shrink)

In the postscript to The Varieties of Religious Experience William James distinguishes two types of belief in the supernatural, conceived as an essential component in religion, crass or piecemeal supernaturalism, on the one hand, and refined supernaturalism on the other.

In this book, T. L. Short places the notorious difficulties of Peirce's important writings in a more productive light, arguing that he wrote philosophy as a scientist, by framing conjectures intended to be refined or superseded in the inquiries they initiate. He argues also that Peirce held that the methods and metaphysics of modern science are amended as inquiry progresses, making metaphysics a branch of empirical knowledge. Additionally, Short shows that Peirce's scientific work expanded empiricism on empirical grounds, grounding his (...) phenomenology and subverting the fact/value dichotomy, and that he understood statistical explanations in nineteenth-century science as reintroducing the idea of final causation, now made empirical. Those innovations underlie Peirce's late ideas of a normative science and of philosophy as a branch of science. Short's rich and original study shows us how to read Peirce's writings and why they are worth reading. (shrink)

If all or any of our MSS. dated from 800 or 900 B.C., it might be of importance to note θέλεις for the regular epic form ⋯θέλεις and even to print it so in the text, otherwise it is negligible. More worthyof attention is the punctuation after ⋯μo⋯μαι. The presence of ὑπίσχoμαι in the next line is held to justify the stop given above, otherwise the comma, as in Gemoll's edition, would be sufficient or more than sufficient. For in accordance (...) with Homeric usage we might read:πατρòς κεϕαλήν μέγαν ὃρκoν ⋯μo⋯μαιμή μέν ⋯γώ μητ' αὐτòς—ὑπίσχoμαι—αἴτιoς εἶναι. (shrink)

Two aspects of Peirce’s mature philosophy seem to me not to have been sufficiently appreciated. They are its empiricist method and its continuity with his scientific research. The research led to and justified the method.1Ground must be cleared before we can proceed. Simplistic ideas of the empirical must be swept aside and Peirce’s empiricism accurately identified. We must also distinguish two theories of meaning that have been associated with empiricist philosophies and show that Peirce combined them ; this will be (...) essential to Section 6. Only then can we get down to work. Peirce’s experimental and other studies of observation showed that a science of.. (shrink)

W. B. Gallie's words about Peirce's cosmology—"the black sheep or white elephant of his philosophical progeny" (1952, p. 216)—have often been quoted, usually as a preface to giving a better account of the animal. That he attributed the view to 'contemporary philosophers' and did not assert it himself has usually been ignored. True, Gallie did argue that the "cosmology is a failure, and an inevitable failure" (p. 236), but he also said that Peirce himself "recognized … that his work in (...) this field was imperfect and sketchy" (p. 215), and he concluded the chapter, and his book, with an extremely sympathetic account of all that is nevertheless of enduring value in that failure. After studying Peirce's writings of his.. (shrink)